Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.48 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573111 | 0.83 | USP30 (0.47) | HSD11B1SPRNAMPTPRMT5WDR77 | |
| SCHEMBL14413519 | 0.74 | HSD11B1 (0.60) | HSD11B1SPRNAMPTDPP4DPP8 | |
| SCHEMBL4789865 | 0.73 | KEAP1 (0.51) | DPP4DPP8ALDH1A1HPGDTDP1 | |
| SCHEMBL8110155 | 0.72 | CTSK (0.58) | — | |
| SCHEMBL4584329 | 0.72 | HRH3 (0.40) | — | |
| SCHEMBL4789292 | 0.70 | NAMPT (0.38) | NAMPTALDH1A1 | |
| SCHEMBL3928801 | 0.70 | HSD11B1 (0.60) | HSD11B1SPRNAMPTRORCCYP11B2 | |
| SCHEMBL20149062 | 0.70 | HSD11B1 (0.63) | HSD11B1SPRNAMPTCYP11B2CHRNB2 | |
| SCHEMBL14276850 | 0.70 | HSD11B1 (0.60) | HSD11B1SPRNAMPTRORCCYP11B2 | |
| SCHEMBL29889680 | 0.69 | HSD11B1 (0.56) | HSD11B1SPRNAMPTDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |