Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.35 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.35 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789865 | 0.73 | KEAP1 (0.51) | — | |
| SCHEMBL4573950 | 0.73 | CTSS (0.45) | HRH3KCNH2 | |
| SCHEMBL4573371 | 0.72 | HSD11B1 (0.48) | — | |
| SCHEMBL4573111 | 0.72 | USP30 (0.47) | — | |
| SCHEMBL4573200 | 0.72 | CTSK (0.57) | HRH3KCNH2 | |
| SCHEMBL4788689 | 0.70 | PDE4B (0.46) | — | |
| SCHEMBL4787927 | 0.69 | CTSK (0.39) | L3MBTL1 | |
| SCHEMBL4573015 | 0.69 | CTSK (0.38) | HRH3KCNH2 | |
| SCHEMBL4614165 | 0.67 | TDP1 (0.32) | — | |
| SCHEMBL4613035 | 0.67 | DPP4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |