Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573371 | 0.83 | HSD11B1 (0.48) | HSD11B1SPRPRMT5WDR77NAMPT | |
| SCHEMBL4789865 | 0.75 | KEAP1 (0.51) | — | |
| SCHEMBL29640084 | 0.73 | HSD11B1 (0.59) | USP30HSD11B1SPRKDM5APRMT5 | |
| SCHEMBL8115969 | 0.72 | CTSK (0.61) | USP30 | |
| SCHEMBL4584329 | 0.72 | HRH3 (0.40) | — | |
| SCHEMBL4573950 | 0.70 | CTSS (0.45) | — | |
| SCHEMBL4573929 | 0.70 | DRD2 (0.40) | NAMPTDRD2 | |
| SCHEMBL4789292 | 0.70 | NAMPT (0.38) | NAMPTUCHL1 | |
| SCHEMBL2806341 | 0.69 | HSD11B1 (0.60) | USP30HSD11B1SPRKDM5APRMT5 | |
| SCHEMBL4787927 | 0.69 | CTSK (0.39) | UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |