SCHEMBL4574168

SCHEMBL4574168

CC(=O)C(Cl)c1cccs1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.46
CES2 O00748 2/20 0.46
CES1 P23141 2/20 0.46
KEAP1 Q14145 1/20 0.46
ALDH1A1 P00352 5/20 0.42
RAB9A P51151 3/20 0.42
NPC1 O15118 2/20 0.42
HPGD P15428 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
GSK3B P49841 1/20 0.41
LMNA P02545 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
POLB P06746 2/20 0.39
ALOX12 P18054 1/20 0.38
DAO P14920 1/20 0.38
GAA P10253 2/20 0.37
MAPT P10636 2/20 0.37
KDM4E B2RXH2 2/20 0.37
GLA P06280 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17685570 0.83 CES2 (0.48) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL6493446 0.82 CES2 (0.47) ALOX5CES2CES1KEAP1ALDH1A1
Benzene SCHEMBL11551889 0.82 CES2 (0.47) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL8853390 0.80 ALOX5 (0.50) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL15695572 0.78 ALOX5 (0.51) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL14408514 0.78 ALOX5 (0.51) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL14828713 0.78 CES2 (0.61) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL11027686 0.77 RORC (0.41) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL11666936 0.76 ALOX5 (0.46) ALOX5CES2CES1KEAP1ALDH1A1
SCHEMBL22815357 0.76 ALOX5 (0.46) ALOX5CES2CES1KEAP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673375-A2 METHOD FOR THE IN SITU PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM OXAZABOROLIDINE-BORANE COMPLEXES, WHICH ARE USED IN ASYMMETRIC REDUCTION REACTIONS PPG-Sipsy (FR) 2006-06-28 EP claimed
WO-2005035540-A2 METHOD FOR THE IN SITU PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM OXAZABOROLIDINE-BORANE COMPLEXES, WHICH ARE USED IN ASYMMETRIC REDUCTION REACTIONS PPG-SIPSY (FR) 2005-04-21 WO claimed
CN-103420898-B Diaryl piperidines analog derivative and the application as Mutiple Targets anti-depression drug thereof SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) 2015-10-28 CN disclosed
CN-103420898-A Diaryl piperidine derivatives and applications thereof as multiple-target-point antidepressants SHANGHAI INST PHARM INDUSTRY 2013-12-04 CN disclosed
WO-2008081476-A2 PROCESS FOR PREPARING DULOXETINE HYDROCHLORIDE CADILA HEALTHCARE LIMITED (IN) 2008-07-10 WO disclosed
EP-1868983-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS LONZA AG (CH) 2007-12-26 EP disclosed
WO-2006087166-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS LONZA AG (CH) 2006-08-24 WO disclosed
EP-1673375-A2 METHOD FOR THE IN SITU PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM OXAZABOROLIDINE-BORANE COMPLEXES, WHICH ARE USED IN ASYMMETRIC REDUCTION REACTIONS PPG-Sipsy (FR) 2006-06-28 EP disclosed
WO-2005035540-A2 METHOD FOR THE IN SITU PREPARATION OF CHIRAL COMPOUNDS DERIVED FROM OXAZABOROLIDINE-BORANE COMPLEXES, WHICH ARE USED IN ASYMMETRIC REDUCTION REACTIONS PPG-SIPSY (FR) 2005-04-21 WO disclosed
WO-2004031168-A2 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF OPTICALLY ACTIVE 3-AMINO-1-(2-THIENYL)-1-PROPANOL DERIVATIVES LONZA AG (CH) 2004-04-15 WO disclosed
WO-2004005307-A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL LONZA AG (CH) 2004-01-15 WO disclosed
WO-2004005220-A2 METHOD FOR ASYMMETRIC RESOLUTION OF A RACEMIC USING DIPROGULIC ACID AND USE OF SAID ACID AS ASYMMETRIC RESOLUTION AGENT PPG-SIPSY (FR) 2004-01-15 WO disclosed
EP-1263711-A1 NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES AstraZeneca AB (SE) 2002-12-11 EP disclosed
WO-2001062704-A1 NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES ASTRAZENECA AB (SE) 2001-08-30 WO disclosed