Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931356 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3081900 | 0.78 | GPR183 (0.54) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL4574384 | 0.77 | RIPK1 (0.43) | ALDH1A1 | |
| SCHEMBL4591026 | 0.77 | RIPK1 (0.43) | ALDH1A1 | |
| SCHEMBL4596716 | 0.77 | AGTR2 (0.41) | ALDH1A1 | |
| SCHEMBL4590621 | 0.77 | AGTR2 (0.41) | ALDH1A1 | |
| SCHEMBL4591030 | 0.77 | RIPK1 (0.43) | ALDH1A1 | |
| SCHEMBL27030606 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL4574185 | 0.75 | DPP4 (0.37) | ALDH1A1 | |
| SCHEMBL14013288 | 0.74 | ALDH1A1 (0.44) | ALDH1A1KDM4ELMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |