Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 7/20 | 0.70 |
| ▸ | SLC5A2 | P31639 | 7/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.63 |
| ▸ | TYR | P14679 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | TTR | P02766 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19668159 | 0.86 | SLC5A1 (0.76) | SLC5A1SLC5A2GAAMAPTCYP19A1 | |
| SCHEMBL30913242 | 0.86 | SLC5A1 (0.76) | SLC5A1SLC5A2GAAMAPTCYP19A1 | |
| SCHEMBL457501 | 0.83 | SLC5A1 (1.00) | SLC5A1SLC5A2GAAMAPTCYP19A1 | |
| SCHEMBL456323 | 0.82 | SLC5A1 (0.72) | SLC5A1SLC5A2GAAMAPTCYP19A1 | |
| SCHEMBL455029 | 0.82 | SLC5A1 (1.00) | SLC5A1SLC5A2GAAMAPTCYP19A1 | |
| SCHEMBL454742 | 0.82 | SLC5A1 (0.69) | SLC5A1SLC5A2GAAMAPTCYP19A1 | |
| SCHEMBL31450931 | 0.80 | CYP19A1 (0.74) | SLC5A1SLC5A2GAAMAPTCYP19A1 | |
| SCHEMBL22842579 | 0.80 | DPP4 (0.53) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL18306242 | 0.79 | SLC5A1 (0.55) | SLC5A1SLC5A2GAAMAPTCYP19A1 | |
| SCHEMBL18306232 | 0.78 | NFKB1 (0.59) | SLC5A1SLC5A2GAAMAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-13 | — | — | US | disclosed |
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-31 | — | — | US | disclosed |
| WO-2012033846-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289128-A1 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS | POLR2H, POLR2A, POLR2E | SLC5A1 2423/4885SLC5A2 3409/4885GAA 1233/4885 |
| US-10800725-B2 | Arylpropionyl-triketone antibacterial agents | POLR2H, POLR2A, POLR2E | SLC5A1 2423/4885SLC5A2 3409/4885GAA 1233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.