SCHEMBL4575689

SCHEMBL4575689

C=C(C)CNc1ccc(O)c(C(=O)O)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.55
MAPT P10636 3/20 0.55
NOX4 Q9NPH5 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
RGS12 O14924 1/20 0.55
EGFR P00533 1/20 0.55
LCK P06239 1/20 0.55
CAMKK2 Q96RR4 1/20 0.55
KDM4C Q9H3R0 5/20 0.54
PPARA Q07869 1/20 0.50
STING1 Q86WV6 1/20 0.50
CSNK2A1 P68400 1/20 0.46
AKR1C3 P42330 2/20 0.45
KLKB1 P03952 1/20 0.45
CTSB P07858 1/20 0.45
MMP9 P14780 1/20 0.45
DNMT1 P26358 1/20 0.45
DNMT3B Q9UBC3 1/20 0.45
DNMT3L Q9UJW3 1/20 0.45
DNMT3A Q9Y6K1 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5961640 0.88 BCL2L1 (0.52) ALDH1A1MAPTNOX4TDP1RGS12
SCHEMBL156253 0.83 ALDH1A1 (0.60) ALDH1A1MAPTNOX4TDP1RGS12
SCHEMBL17849006 0.80 KDM4C (0.63) ALDH1A1MAPTNOX4TDP1RGS12
SCHEMBL12862660 0.78 ALDH1A1 (0.57) ALDH1A1MAPTNOX4TDP1RGS12
SCHEMBL5720697 0.77 KDM4E (0.54) ALDH1A1MAPTTDP1PPARAPKM
SCHEMBL346822 0.76 MAPT (0.56) ALDH1A1MAPTNOX4TDP1RGS12
SCHEMBL29381797 0.76 MAPT (0.56) ALDH1A1MAPTNOX4TDP1RGS12
SCHEMBL21451256 0.76 ALDH1A1 (0.56) ALDH1A1MAPTNOX4TDP1RGS12
SCHEMBL9621441 0.75 KDM4E (0.47) ALDH1A1MAPTTDP1AKR1C3PKM
SCHEMBL170522 0.75 KDM4C (0.62) ALDH1A1MAPTTDP1KDM4CCSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1221929-B1 METHOD FOR IMPROVING THE STAY-ON PROPERTIES OF COSMETIC COMPOSITIONS OREAL (FR) 2006-09-06 EP claimed
US-6730133-B1 ENZYME IMMOBILIZED IN A SOL-GEL MATRIX; 2-ELECTRON OXIDOREDUCTASES, 4-ELECTRON OXIDOREDUCTASES AND PEROXIDASES; HYDROGEN PEROXIDE; HEAT STABILITY L'OREAL S.A. (FR) 2004-05-04 US claimed
EP-0627960-B1 COLLOIDAL AND CONCENTRATED SOLUTION OF MONOCRYSTAL-PARTICLES FROM METALLIC OXIDES, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATIONS RHONE POULENC CHIMIE (FR) 1996-11-27 EP claimed
US-10064792-B2 Hybrid coated cosmetic powders and methods of making and using same KOBO PRODUCTS INC. (US) 2018-09-04 US disclosed
US-20080014233-A1 HYBRID COATED COSMETIC POWDERS AND METHODS OF MAKING AND USING SAME KOBO PRODUCTS INC. 2008-01-17 US disclosed
WO-2005099651-A1 HYBRID COATED COSMETIC POWDERS AND METHODS OF MAKING AND USING SAME KOBO PRODUCTS, INC. (US) 2005-10-27 WO disclosed
US-20040234613-A1 Hybrid coated cosmetic powders and methods of making and using same KOBO PRODUCTS, INC. 2004-11-25 US disclosed
US-6730133-B1 ENZYME IMMOBILIZED IN A SOL-GEL MATRIX; 2-ELECTRON OXIDOREDUCTASES, 4-ELECTRON OXIDOREDUCTASES AND PEROXIDASES; HYDROGEN PEROXIDE; HEAT STABILITY L'OREAL S.A. (FR) 2004-05-04 US disclosed
US-6352699-B1 SOL/GEL TYPE COMPOSITION OBTAINED BY MIXING AT LEAST ONE ORGANOMETALLIC COMPOUND, AT LEAST ONE FUNCTIONALIZED ORGANIC POLYMER OR A PRECURSOR OF SAID POLYMER, WATER L'OREAL (FR) 2002-03-05 US disclosed
US-5556897-A METAL COMPOUND, ACRYLIC MONOMERS, TRIALKYLBORON SUN MEDICAL CO., LTD. (JP) 1996-09-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040234613-A1 Hybrid coated cosmetic powders and methods of making and using same STK11, CLK1, CLK2 ALDH1A1 4468/4885MAPT 1785/4885NOX4 4608/4885
US-10064792-B2 Hybrid coated cosmetic powders and methods of making and using same STK11, CLK1, CLK2 ALDH1A1 4468/4885MAPT 1785/4885NOX4 4608/4885
US-20080014233-A1 HYBRID COATED COSMETIC POWDERS AND METHODS OF MAKING AND USING SAME STK11, CLK1, CLK2 ALDH1A1 4468/4885MAPT 1785/4885NOX4 4608/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.