Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575681 | 1.00 | OPRD1 (0.59) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL13440481 | 0.86 | OPRD1 (0.64) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL4576016 | 0.86 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL4575933 | 0.86 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL7923037 | 0.86 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL7994344 | 0.86 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL6374535 | 0.86 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL4575679 | 0.86 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL4575840 | 0.86 | OPRD1 (0.68) | OPRD1CYP1A2CYP3A4CYP2C9HPGD | |
| SCHEMBL4591682 | 0.84 | OPRD1 (0.51) | OPRD1CYP1A2CYP3A4OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080193383-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | ENTA HOLDING LLC | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080193383-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | OPRD1, OPRM1, OPRK1 | OPRD1 1/4885CYP1A2 751/4885CYP3A4 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.