Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 6/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457627 | 0.87 | DPP4 (0.34) | GPR119F2RDPP4DPP8DPP9 | |
| SCHEMBL458011 | 0.86 | ACACB (0.35) | GPR119ACACBCHEK2F2RDPP4 | |
| SCHEMBL459423 | 0.86 | GPR119 (0.41) | GPR119F2RRET | |
| SCHEMBL457195 | 0.80 | PDE4B (0.42) | GPR119 | |
| SCHEMBL152374 | 0.80 | GPR119 (0.39) | GPR119DPP4 | |
| SCHEMBL459780 | 0.80 | ACACB (0.32) | GPR119SCN9AACACBDPP4DPP8 | |
| SCHEMBL460034 | 0.79 | CHRM2 (0.38) | ACACBRET | |
| SCHEMBL462498 | 0.78 | RET (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL459391 | 0.78 | PDE4B (0.42) | GPR119 | |
| SCHEMBL458181 | 0.78 | PDE4B (0.43) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |