Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 12/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.42 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14119801 | 0.92 | HPGDS (0.52) | HPGDSL3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL15070464 | 0.87 | HPGDS (0.55) | HPGDSL3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL459764 | 0.80 | HPGDS (0.64) | HPGDSL3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL27922 | 0.74 | HPGDS (0.53) | HPGDSL3MBTL1 | |
| SCHEMBL15051376 | 0.74 | GFER (0.45) | HPGDS | |
| SCHEMBL14119432 | 0.73 | HPGDS (0.55) | HPGDS | |
| SCHEMBL8730118 | 0.72 | L3MBTL3 (0.44) | L3MBTL3L3MBTL1TP53BP1MBTD1SPHK1 | |
| SCHEMBL14217337 | 0.72 | SPHK1 (0.51) | L3MBTL3L3MBTL1TP53BP1MBTD1SPHK1 | |
| SCHEMBL23000066 | 0.71 | HPGDS (0.64) | HPGDSL3MBTL3 | |
| SCHEMBL6760657 | 0.70 | CYP19A1 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2527340-B1 | PIPERAZINE COMPOUND HAVING A PGDS INHIBITORY EFFECT | TAIHO PHARMACEUTICAL CO LTD (JP) | 2016-08-17 | — | — | EP | disclosed |
| EP-2615084-B1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | TAIHO PHARMACEUTICAL CO LTD (JP) | 2016-01-06 | — | — | EP | disclosed |
| US-9181183-B2 | Prostaglandin D synthase inhibitory piperidine compounds | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-11-10 | — | — | US | disclosed |
| CN-103080086-B | Prostaglandin D synthase inhibitory piperidine compounds | TAIHO PHARMACEUTICAL CO LTD | 2014-11-05 | — | — | CN | disclosed |
| CN-102712626-B | Piperazine compounds having PGDS inhibitory effect | TAIHO PHARMACEUTICAL CO LTD | 2014-09-17 | — | — | CN | disclosed |
| US-8765750-B2 | Piperazine compound having a PGDS inhibitory effect | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-07-01 | — | — | US | disclosed |
| EP-2615084-A1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | Taiho Pharmaceutical Co., Ltd. (JP) | 2013-07-17 | — | — | EP | disclosed |
| US-20130165438-A1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2013-06-27 | — | — | US | disclosed |
| CN-103080086-A | Prostaglandin D synthase inhibitory piperidine compounds | TAIHO PHARMACEUTICAL CO LTD | 2013-05-01 | — | — | CN | disclosed |
| US-20120309760-A1 | PIPERAZINE COMPOUND HAVING A PGDS INHIBITORY EFFECT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-12-06 | — | — | US | disclosed |
| CN-102712626-A | Piperazine compounds having PGDS inhibitory effect | TAIHO PHARMACEUTICAL CO LTD | 2012-10-03 | — | — | CN | disclosed |
| WO-2012033069-A1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | 大鵬薬品工業株式会社 (JP) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309760-A1 | PIPERAZINE COMPOUND HAVING A PGDS INHIBITORY EFFECT | GRIK5, GRK5, KCNJ5 | HPGDS 14/4885L3MBTL3 4147/4885L3MBTL1 3806/4885 |
| US-20130165438-A1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | PTGIS, PTGS1, PTGDR | HPGDS 5/4885L3MBTL3 4875/4885L3MBTL1 4781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.