Guanine

Guanine

SCHEMBL4577873

Cc1c[nH]c(=O)[nH]c1=O.Nc1nc2[nH]cnc2c(=O)[nH]1.Nc1ncnc2[nH]cnc12

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 1/20 0.43
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
GLA P06280 1/20 0.39
PMP22 Q01453 1/20 0.39
HSD17B10 Q99714 1/20 0.39
PNP P00491 2/20 0.35
XDH P47989 1/20 0.33
DYRK1A Q13627 1/20 0.32
MAPT P10636 1/20 0.31
MITF O75030 1/20 0.31
TP53 P04637 1/20 0.31
THRB P10828 1/20 0.31
ALOX15 P16050 1/20 0.31
HBB P68871 1/20 0.31
HIF1A Q16665 1/20 0.31
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL17542295 0.92 ATAD2 (0.36) ATAD2KDM4EALDH1A1LMNAGLA
Guanine SCHEMBL4460112 0.92 ATAD2 (0.51) ATAD2KDM4EALDH1A1LMNAGLA
Guanine SCHEMBL5097008 0.91 ATAD2 (0.36) ATAD2KDM4EALDH1A1LMNAGLA
Adenine SCHEMBL8472509 0.91 ATAD2 (0.53) ATAD2ALDH1A1LMNAPMP22PNP
Adenine SCHEMBL3474048 0.91 ATAD2 (0.53) ATAD2ALDH1A1LMNAPMP22PNP
Adenine SCHEMBL4633065 0.91 ATAD2 (0.53) ATAD2ALDH1A1LMNAPMP22PNP
Guanine SCHEMBL9468293 0.90 ATAD2 (0.35) ATAD2KDM4EALDH1A1LMNAGLA
Guanine SCHEMBL15718980 0.87 KDM4E (0.33) ATAD2KDM4EALDH1A1LMNAGLA
Guanine SCHEMBL21223789 0.87 ALDH1A1 (0.50) KDM4EALDH1A1LMNAGLAPMP22
Guanine SCHEMBL1831275 0.87 ALDH1A1 (0.50) KDM4EALDH1A1LMNAGLAPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7319026-B2 Amino acid-producing bacteria and a process for preparing L-amino acids DEGUSSA AG (DE) 2008-01-15 US disclosed
EP-1481075-A2 AMINO ACID-PRODUCING BACTERIA AND A PROCESS FOR PREPARING L-AMINO ACIDS Degussa AG (DE) 2004-12-01 EP disclosed
US-20040082040-A1 Amino acid-producing bacteria and a process for preparing L-amino acids DEGUSSA AG 2004-04-29 US disclosed
WO-2003074719-A2 AMINO ACID-PRODUCING BACTERIA AND A PROCESS FOR PREPARING L-AMINO ACIDS DEGUSSA AG (DE) 2003-09-12 WO disclosed
WO-1997002279-A1 METHODS AND COMPOSITIONS FOR MODULATION AND INHIBITION OF TELOMERASE CTRC RESEARCH FOUNDATION (US) 1997-01-23 WO disclosed