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Guanine

Guanine

SCHEMBL9468293

Cc1c[nH]c(=O)[nH]c1=O.Nc1cc[nH]c(=O)n1.Nc1nc2[nH]cnc2c(=O)[nH]1.Nc1ncnc2[nH]cnc12.P

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ ATAD2 Q6PL18 1/20 0.35
▸ DYRK1A Q13627 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ GLA P06280 1/20 0.33
▸ PMP22 Q01453 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ XDH P47989 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL5097008 0.99 ATAD2 (0.36) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL9468221 0.96 KDM4E (0.32) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL15718980 0.95 KDM4E (0.33) ATAD2DYRK1AKDM4EALDH1A1LMNA
Adenine SCHEMBL4579096 0.92 ATAD2 (0.41) ATAD2
Guanine SCHEMBL4007020 0.92 ATAD2 (0.41) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL4577873 0.90 ATAD2 (0.43) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL17542295 0.89 ATAD2 (0.36) ATAD2DYRK1AKDM4EALDH1A1LMNA
Guanine SCHEMBL1730016 0.88 DYRK1A (0.42) DYRK1AKDM4EALDH1A1LMNAGLA
Adenine SCHEMBL6227731 0.88 ATAD2 (0.37) ATAD2
Guanine SCHEMBL2636585 0.85 KDM4E (0.38) DYRK1AKDM4EALDH1A1LMNAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5182269-A Depolymerized DNA CRINOS INDUSTRIA FARMACOBIOLOGICA SPA (IT) 1993-01-26 — — US disclosed