Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL9468293 | 0.99 | ATAD2 (0.35) | ATAD2DYRK1AKDM4EALDH1A1LMNA | |
| Guanine SCHEMBL15718980 | 0.96 | KDM4E (0.33) | ATAD2DYRK1AKDM4EALDH1A1LMNA | |
| Guanine SCHEMBL9468221 | 0.95 | KDM4E (0.32) | ATAD2DYRK1AKDM4EALDH1A1LMNA | |
| Guanine SCHEMBL4007020 | 0.93 | ATAD2 (0.41) | ATAD2DYRK1AKDM4EALDH1A1LMNA | |
| Adenine SCHEMBL4579096 | 0.93 | ATAD2 (0.41) | ATAD2 | |
| Guanine SCHEMBL4577873 | 0.91 | ATAD2 (0.43) | ATAD2DYRK1AKDM4EALDH1A1LMNA | |
| Guanine SCHEMBL17542295 | 0.90 | ATAD2 (0.36) | ATAD2DYRK1AKDM4EALDH1A1LMNA | |
| Guanine SCHEMBL1730016 | 0.89 | DYRK1A (0.42) | DYRK1AKDM4EALDH1A1LMNAGLA | |
| Adenine SCHEMBL6227731 | 0.89 | ATAD2 (0.37) | ATAD2 | |
| Guanine SCHEMBL2636585 | 0.86 | KDM4E (0.38) | DYRK1AKDM4EALDH1A1LMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200197351-A1 | TRIVALENT AND DIVALENT CATIONS AS ADMINISTRABLE AGENTS FOR INCREASED PROCESSIVITY AND IMPROVED FIDELITY OF REVERSE TRANSCRIPTASE IN TELOMERASE AND IN NUCLEIC ACID POLYMERASES | FILLER AARON GERSHON (US) | 2020-06-25 | — | — | US | disclosed |
| US-10364272-B2 | Conformationally-preorganized, miniPEG-containing gamma-peptide nucleic acids | CARNEGIE MELLON UNIVERSITY (US) | 2019-07-30 | — | — | US | disclosed |
| US-10093700-B2 | Conformationally-preorganized, MiniPEG-containing gamma-peptide nucleic acids | CARNEGIE MELLON UNIVERSITY (US) | 2018-10-09 | — | — | US | disclosed |
| US-20160096867-A1 | CONFORMATIONALLY-PREORGANIZED, MiniPEG-CONTAINING GAMMA-PEPTIDE NUCLEIC ACIDS | CARNEGIE MELLON UNIVERSITY CENTER FOR TECHNOLOGY TRANSFER & ENTERPRISE (US) | 2016-04-07 | — | — | US | disclosed |
| US-9193758-B2 | Conformationally-preorganized, miniPEG-containing γ-peptide nucleic acids | CARNEGIE MELLON UNIVERSITY CENTER FOR TECHNOLOGY TRANSFER & ENTERPRISE (US) | 2015-11-24 | — | — | US | disclosed |
| US-7396365-B2 | Method for inserting a fusion cage having a height substantially the same as the height between adjacent vertebral endplates | WARSAW ORTHOPEDIC, INC. (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1554995-B1 | Self-broaching, rotatable, push-in interbody spinal implant | WARSAW ORTHOPEDIC INC (US) | 2007-12-12 | — | — | EP | disclosed |
| US-7056342-B2 | Self-broaching, rotatable, push-in interbody spinal fusion implant and method for deployment thereof | SDGI HOLDINGS, INC. (US) | 2006-06-06 | — | — | US | disclosed |
| US-20050216083-A1 | Method for inserting a fusion cage having a height substantially the same as the height between adjacent vertebral endplates | WARSAW ORTHOPEDIC, INC. | 2005-09-29 | — | — | US | disclosed |
| EP-1554995-A2 | Self-broaching, rotatable, push-in interbody spinal implant | Michelson, Gary Karlin (US) | 2005-07-20 | — | — | EP | disclosed |
| EP-1131020-B1 | SELF-BROACHING, ROTATABLE, PUSH-IN INTERBODY FUSION IMPLANT | MICHELSON GARY K (US) | 2005-04-20 | — | — | EP | disclosed |
| US-20030149483-A1 | Self-broaching, rotatable, push-in interbody spinal fusion implant and method for deployment thereof | WARSAW ORTHOPEDIC, INC. | 2003-08-07 | — | — | US | disclosed |
| EP-1131020-A4 | SELF-BROACHING, ROTATABLE, PUSH-IN INTERBODY FUSION IMPLANT AND METHOD FOR DEPLOYMENT THEREOF | MICHELSON GARY K (US) | 2003-06-11 | — | — | EP | disclosed |
| US-6537320-B1 | Self-broaching, rotatable, push-in interbody spinal fusion implant and method for deployment thereof | WARSAW ORTHOPEDIC, INC. | 2003-03-25 | — | — | US | disclosed |
| US-20010047207-A1 | Self-broaching, rotatable, push-in interbody spinal fusion implant and method for deployment thereof | WARSAW ORTHOPEDIC, INC | 2001-11-29 | — | — | US | disclosed |
| EP-1131020-A1 | SELF-BROACHING, ROTATABLE, PUSH-IN INTERBODY FUSION IMPLANT AND METHOD FOR DEPLOYMENT THEREOF | MICHELSON, Gary Karlin (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000025707-A9 | SELF-BROACHING, ROTATABLE, PUSH-IN INTERBODY FUSION IMPLANT AND METHOD FOR DEPLOYMENT THEREOF | MICHELSON GARY K (US) | 2000-11-02 | — | — | WO | disclosed |
| WO-2000025707-A1 | SELF-BROACHING, ROTATABLE, PUSH-IN INTERBODY FUSION IMPLANT AND METHOD FOR DEPLOYMENT THEREOF | MICHELSON GARY K (US) | 2000-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364272-B2 | Conformationally-preorganized, miniPEG-containing gamma-peptide nucleic acids | POLL, PCNA, POLG | ATAD2 2136/4885DYRK1A 4770/4885KDM4E 4658/4885 |
| US-10093700-B2 | Conformationally-preorganized, MiniPEG-containing gamma-peptide nucleic acids | POLL, PCNA, POLG | ATAD2 2136/4885DYRK1A 4770/4885KDM4E 4658/4885 |
| US-20160096867-A1 | CONFORMATIONALLY-PREORGANIZED, MiniPEG-CONTAINING GAMMA-PEPTIDE NUCLEIC ACIDS | POLL, PCNA, POLG | ATAD2 2136/4885DYRK1A 4770/4885KDM4E 4658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.