Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | C1S | P09871 | 2/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4129531 | 0.88 | IL6 (0.41) | IL6ALDH1A1KDM4E | |
| SCHEMBL4140035 | 0.85 | IL6 (0.42) | IL6 | |
| SCHEMBL4142446 | 0.84 | LMNA (0.46) | IL6TDP1ALDH1A1MAPTLMNA | |
| SCHEMBL13571452 | 0.83 | IL6 (0.41) | IL6PLA2G1BTDP1ATG4BALDH1A1 | |
| SCHEMBL4580605 | 0.81 | IL6 (0.46) | IL6TDP1ALDH1A1MAPTHPGD | |
| SCHEMBL1315415 | 0.81 | NR3C1 (0.42) | PLA2G1BTDP1ATG4BALDH1A1MAPT | |
| SCHEMBL4581403 | 0.80 | IL6 (0.51) | IL6TDP1ALDH1A1MAPTLMNA | |
| SCHEMBL4581832 | 0.79 | ACHE (0.41) | IL6TDP1ALDH1A1MAPTLMNA | |
| SCHEMBL6114280 | 0.79 | IL6 (0.42) | IL6TDP1ALDH1A1MAPTHPGD | |
| SCHEMBL14015605 | 0.79 | KMT2A (0.36) | IL6PLA2G1BTDP1ATG4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-A1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | Santen Pharmaceutical Co., Ltd (JP) | 2008-11-26 | — | — | EP | disclosed |