Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | IL6 | P05231 | 6/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4142446 | 0.88 | LMNA (0.46) | IL6MAPTSMN1; SMN2KDM4ETSHR | |
| SCHEMBL4581834 | 0.83 | IL6 (0.44) | ACHESMPD3IL6NPC1MAPT | |
| SCHEMBL1314299 | 0.82 | MAPT (0.46) | ACHESMPD3NPC1MAPTSMN1; SMN2 | |
| SCHEMBL13639369 | 0.80 | ACHE (0.40) | ACHESMPD3BCHENPC1MAPT | |
| SCHEMBL4129531 | 0.79 | IL6 (0.41) | IL6KDM4EALDH1A1 | |
| SCHEMBL4580599 | 0.79 | IL6 (0.41) | IL6MAPTKDM4ELMNATDP1 | |
| SCHEMBL4140035 | 0.79 | IL6 (0.42) | IL6 | |
| SCHEMBL4135861 | 0.79 | IL6 (0.66) | ACHESMPD3IL6 | |
| SCHEMBL15295468 | 0.76 | MAPT (0.44) | IL6MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL6114280 | 0.76 | IL6 (0.42) | IL6MAPTSMN1; SMN2LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-A1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | Santen Pharmaceutical Co., Ltd (JP) | 2008-11-26 | — | — | EP | disclosed |