Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14015597 | 0.88 | MAPT (0.48) | MAPTLMNATP53HSD17B10TDP1 | |
| SCHEMBL14015835 | 0.86 | IL6 (0.39) | MAPTLMNAHSD17B10TDP1HTR2A | |
| SCHEMBL14015810 | 0.85 | IL6 (0.38) | ACHEMAPTLMNAHSD17B10TDP1 | |
| SCHEMBL14878774 | 0.82 | ALOX15 (0.41) | MAPTLMNATDP1HTR2AHTR2C | |
| SCHEMBL13639363 | 0.82 | KMT2A (0.38) | MAPTTP53HSD17B10TDP1KDM4E | |
| SCHEMBL13639336 | 0.81 | HCRTR1 (0.37) | MAPTLMNAKDM4EFAAHDRD3 | |
| SCHEMBL14015609 | 0.81 | DRD2 (0.36) | MAPTLMNATP53HSD17B10TDP1 | |
| SCHEMBL12087358 | 0.80 | ACHE (0.40) | ACHESMPD3MAPTLMNANPC1 | |
| SCHEMBL13639370 | 0.80 | IL6 (0.38) | MAPTNPC1TP53HSD17B10RAB9A | |
| SCHEMBL4581832 | 0.80 | ACHE (0.41) | ACHESMPD3MAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |