SCHEMBL4582299

SCHEMBL4582299

Cc1n[nH]c(=O)c(-c2ccc(F)cc2Cl)c1-c1ccc(Cl)s1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
DRD1 P21728 3/20 0.35
HSD11B1 P28845 1/20 0.34
P2RX7 Q99572 2/20 0.34
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
PTPN11 Q06124 1/20 0.33
AKR1B1 P15121 1/20 0.33
TP53 P04637 1/20 0.32
CDC7 O00311 1/20 0.32
DBF4 Q9UBU7 1/20 0.32
PIK3R1 P27986 1/20 0.32
PIK3CA P42336 1/20 0.32
TNIK Q9UKE5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4582132 0.88 DRD1 (0.34) NPSR1L3MBTL1DRD1PIK3R1PIK3CA
SCHEMBL4583334 0.83 NOTUM (0.38) NPSR1L3MBTL1DRD1
SCHEMBL4582585 0.81 GNRHR (0.37) NPSR1L3MBTL1
SCHEMBL4582481 0.77 NPSR1 (0.36) NPSR1L3MBTL1DRD1P2RX7
SCHEMBL4582691 0.73 IKBKE (0.45) NPSR1L3MBTL1
SCHEMBL17514492 0.73 ESR1 (0.48) HSD11B1NISCHTP53
SCHEMBL4608946 0.73 TYMP (0.46) NPSR1L3MBTL1TP53
SCHEMBL4582968 0.71 USP1 (0.33) DRD1
SCHEMBL2347927 0.71 PSD (0.39) NPSR1DRD1
SCHEMBL4600738 0.70 GABRA1 (0.40) NPSR1DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1972623-A1 Arylpyridazines as fungicides Bayer CropScience AG (DE) 2008-09-24 EP disclosed