SCHEMBL4582323

SCHEMBL4582323

COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](F)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.53
P2RY14 Q15391 5/20 0.51
P2RY2 P41231 10/20 0.46
P2RY6 Q15077 8/20 0.46
P2RY4 P51582 4/20 0.45
SLC28A1 O00337 1/20 0.44
SLC28A2 O43868 1/20 0.44
SLC29A1 Q99808 1/20 0.44
SLC28A3 Q9HAS3 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19026959 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL15302883 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL26647610 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL22983983 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL17090835 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL22983986 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL19026961 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL22983977 1.00 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL17556244 0.93 TYMP (0.53) TYMPP2RY14P2RY2P2RY6P2RY4
SCHEMBL3316264 0.93 P2RY14 (0.51) TYMPP2RY14P2RY2P2RY6P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025047679-A1 STABLE TARGET EDITING GUIDE RNA HAVING PHOSPHATE MOIETY MODIFICATION INTRODUCED THEREINTO 学校法人福岡大学 2025-03-06 WO disclosed
EP-3296306-B1 BASE-PROTECTED OLIGONUCLEOTIDE AJINOMOTO KK (JP) 2022-11-09 EP disclosed
EP-2816053-B1 BASE-PROTECTED OLIGONUCLEOTIDE AJINOMOTO KK (JP) 2021-03-24 EP disclosed
US-10730904-B2 Method for liquid-phase synthesis of nucleic acid TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-08-04 US disclosed
EP-2921499-B1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACIDS TAKEDA PHARMACEUTICALS CO (JP) 2020-01-22 EP disclosed
EP-2928877-B1 DISULFIDE MASKED PRODRUG COMPOSITIONS AND METHODS MERCK SHARP & DOHME (US) 2020-01-22 EP disclosed
US-20190135852-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-05-09 US disclosed
US-20180207197-A1 OLIGONUCLEOTIDE DERIVATIVE KYOWA HAKKO KIRIN CO., LTD. (JP) 2018-07-26 US disclosed
EP-3296306-A1 BASE-PROTECTED OLIGONUCLEOTIDE AJINOMOTO CO., INC. (JP) 2018-03-21 EP disclosed
US-9884886-B2 Disulfide masked prodrug compositions and methods MERCK SHARP & DOHME (US) 2018-02-06 US disclosed
US-20150315226-A1 DISULFIDE MASKED PRODRUG COMPOSITIONS AND METHODS MERCK SHARP & DOHME CORP. (US) 2015-11-05 US disclosed
EP-2921499-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID Takeda Pharmaceutical Company Limited (JP) 2015-09-23 EP disclosed
US-20150080565-A1 OLIGONUCLEOTIDE WITH PROTECTED BASE AJINOMOTO CO., INC. (JP) 2015-03-19 US disclosed
EP-2816053-A1 BASE-PROTECTED OLIGONUCLEOTIDE Ajinomoto Co., Inc. (JP) 2014-12-24 EP disclosed
US-8846885-B2 Oligonucleotide with protected base AJINOMOTO CO., INC. (JP) 2014-09-30 US disclosed
US-20130267697-A1 OLIGONUCLEOTIDE WITH PROTECTED BASE AJINOMOTO CO., INC. (JP) 2013-10-10 US disclosed
EP-0593901-B2 Oligoribonucleotide- and ribozyme-analoguer with terminal 3',3'- and 5',5'-bonds respectively SANOFI AVENTIS DEUTSCHLAND (DE) 2008-04-09 EP disclosed
US-6420546-B1 OLIGONUCLEOTIDE FOR USE IN THE TREATMENT OF VIRAL DISEASE AND CANCER AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-07-16 US disclosed
EP-0593901-B1 Oligoribonucleotide- and ribozyme-analoguer with terminal 3',3'- and 5',5'-bonds respectively HOECHST AG (DE) 1997-04-16 EP disclosed
EP-0593901-A2 Oligoribonucleotide- and ribozyme-analoguer with terminal 3',3'- and 5',5'-bonds respectively HOECHST AKTIENGESELLSCHAFT (DE) 1994-04-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190135852-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID RNGTT, POLR2H, POLR2E TYMP 165/4885P2RY14 3644/4885P2RY2 3721/4885
US-20150080565-A1 OLIGONUCLEOTIDE WITH PROTECTED BASE POLRMT, POLN, RNGTT TYMP 26/4885P2RY14 2169/4885P2RY2 2844/4885
US-20150315226-A1 DISULFIDE MASKED PRODRUG COMPOSITIONS AND METHODS GSS, GSTP1, GSTM2 TYMP 333/4885P2RY14 2593/4885P2RY2 1949/4885
US-10730904-B2 Method for liquid-phase synthesis of nucleic acid RNGTT, POLR2H, POLR2E TYMP 257/4885P2RY14 3902/4885P2RY2 3590/4885
US-20180207197-A1 OLIGONUCLEOTIDE DERIVATIVE POLRMT, POLR2E, POLR2H TYMP 302/4885P2RY14 3254/4885P2RY2 3001/4885
US-20130267697-A1 OLIGONUCLEOTIDE WITH PROTECTED BASE POLRMT, POLN, RNGTT TYMP 26/4885P2RY14 2169/4885P2RY2 2844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.