Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373941 | 0.84 | DPP4 (0.43) | KDM4EALDH1A1LMNADPP4 | |
| SCHEMBL4377187 | 0.84 | DPP4 (0.43) | KDM4EALDH1A1LMNADPP4 | |
| SCHEMBL4371128 | 0.83 | TRPM8 (0.41) | GPR139ALDH1A1 | |
| SCHEMBL4371626 | 0.82 | ALDH1A1 (0.38) | HDAC4HDAC7HDAC5CNR2KDM4E | |
| SCHEMBL15169778 | 0.76 | HDAC4 (0.44) | HDAC4HDAC7HDAC5CNR2CYP26A1 | |
| SCHEMBL4584586 | 0.74 | GAA (0.46) | HDAC4HDAC7HDAC5CNR2CES2 | |
| SCHEMBL23000166 | 0.74 | MTOR (0.60) | HDAC4HDAC7HDAC5CNR2MTOR | |
| SCHEMBL4380602 | 0.74 | PRCP (0.41) | HDAC4HDAC7HDAC5CNR2CYP26A1 | |
| SCHEMBL19305439 | 0.72 | HDAC4 (0.43) | HDAC4HDAC7HDAC5CNR2CYP26A1 | |
| SCHEMBL15081379 | 0.72 | CTSS (0.46) | HDAC4HDAC7HDAC5CNR2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |