Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387389 | 0.83 | CNR2 (0.46) | GAACNR2LMNASMN1; SMN2CTSA | |
| SCHEMBL4374417 | 0.82 | ADRB2 (0.40) | KMT2AHIF1ACTSA | |
| SCHEMBL4371317 | 0.80 | ALDH1A1 (0.48) | GAAALDH1A1LMNAHDAC3HDAC6 | |
| SCHEMBL4377187 | 0.80 | DPP4 (0.43) | ALDH1A1KMT2ALMNADPP4 | |
| SCHEMBL4373941 | 0.80 | DPP4 (0.43) | ALDH1A1KMT2ALMNADPP4 | |
| SCHEMBL4371626 | 0.76 | ALDH1A1 (0.38) | GAACNR2ALDH1A1MEN1KMT2A | |
| SCHEMBL15269542 | 0.75 | ROCK2 (0.47) | GAACNR2ALDH1A1MEN1KMT2A | |
| SCHEMBL4584032 | 0.74 | HDAC4 (0.43) | GAACNR2ALDH1A1CES2CES1 | |
| SCHEMBL25375819 | 0.73 | GAA (0.50) | GAACNR2MEN1KMT2ACES2 | |
| SCHEMBL4596259 | 0.71 | CNR2 (0.43) | GAACNR2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |