Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.41 |
| ▸ | CCR5 | P51681 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4244588 | 0.83 | CCR5 (0.46) | CCR5 | |
| SCHEMBL4586423 | 0.82 | CCR5 (0.41) | OPRM1OPRD1OPRK1CCR5DRD2 | |
| SCHEMBL4585402 | 0.81 | CCR5 (0.41) | OPRM1OPRD1OPRK1CCR5KDM4E | |
| SCHEMBL4585393 | 0.81 | CCR5 (0.53) | OPRM1OPRD1OPRK1CCR5 | |
| SCHEMBL4587616 | 0.80 | CCR5 (0.42) | OPRM1OPRD1OPRK1CCR5DRD2 | |
| SCHEMBL4244585 | 0.79 | CCR5 (0.46) | CCR5CYP3A4 | |
| SCHEMBL4585491 | 0.78 | CCR5 (0.44) | OPRM1OPRD1OPRK1CCR5ALDH1A1 | |
| SCHEMBL5056837 | 0.77 | CCR5 (0.51) | OPRM1CCR5KDM4EALDH1A1CYP3A4 | |
| SCHEMBL5057871 | 0.77 | CCR5 (0.44) | CCR5KDM4EALDH1A1CYP3A4 | |
| SCHEMBL5056393 | 0.74 | CCR5 (0.49) | OPRM1CCR5CYP3A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |