Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29629433 | 0.73 | COMT (0.39) | NISCHNPY5RMTORADKMAPK13 | |
| SCHEMBL313808 | 0.71 | MASP2 (0.44) | NPY5RDYRK1AHPGDS | |
| SCHEMBL19463621 | 0.70 | PIN1 (0.43) | MAPK13KDM4EALDH1A1DYRK1A | |
| SCHEMBL16631958 | 0.70 | MEN1 (0.42) | MEN1KMT2ARXFP1CACNA1BAPBA1 | |
| SCHEMBL4967794 | 0.68 | PDE4A (0.44) | NPY5RMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL14831001 | 0.67 | ADORA2A (0.32) | KDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7454459 | 0.65 | PDE3B (0.50) | NPY5RALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL3480692 | 0.64 | — | — | |
| SCHEMBL28047898 | 0.64 | SCN2A (0.38) | NPY5RSCN2ARECQLHPGDS | |
| SCHEMBL15541493 | 0.64 | PI4KA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020149715-A1 | PYRROLOPYRIDINE DERIVATIVE AND USE THEREOF IN PREVENTION AND TREATMENT OF PROTEIN KINASE-RELATED DISEASE | 주식회사 보로노이 | 2020-07-23 | — | — | WO | claimed |
| EP-4010080-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028643-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| EP-3386498-A1 | METHOD FOR MODULATING AUTOPHAGY AND APPLICATIONS THEREOF | Jawaharlal Nehru Centre For Advanced Scientific Research (IN) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098467-A1 | METHOD FOR MODULATING AUTOPHAGY AND APPLICATIONS THEREOF | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (IN) | 2017-06-15 | — | — | WO | disclosed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |