Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | HPGDS | O60760 | 3/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.33 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | STK32B | Q9NY57 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026285 | 0.74 | CYP2A6 (0.43) | NPY5RHPGDS | |
| SCHEMBL7220055 | 0.74 | NPY5R (0.38) | NPY5RHPGDS | |
| SCHEMBL1983843 | 0.72 | MASP2 (0.39) | MASP2LTA4HIKBKETBK1 | |
| SCHEMBL4585526 | 0.71 | NISCH (0.36) | NPY5RHPGDSDYRK1A | |
| SCHEMBL28175769 | 0.69 | GSK3B (0.36) | NPY5RHPGDS | |
| SCHEMBL15880173 | 0.69 | HPGDS (0.33) | NPY5RHPGDS | |
| SCHEMBL27647142 | 0.69 | HPGDS (0.33) | NPY5RHPGDS | |
| SCHEMBL1441687 | 0.68 | ALDH1A1 (0.37) | NPY5RHPGDS | |
| SCHEMBL844876 | 0.68 | AKT1 (0.42) | NPY5RHPGDS | |
| SCHEMBL8816338 | 0.68 | PIN1 (0.43) | NPY5RHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4341264-B1 | PYRROLOPIRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LEISHMANIASIS | DRUGS FOR NEGLECTED DISEASES INITIATIVE (CH) | 2025-04-02 | — | — | EP | claimed |
| EP-4341264-A1 | PYRROLOPIRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LEISHMANIASIS | Drugs for Neglected Diseases Initiative (CH) | 2024-03-27 | — | — | EP | claimed |
| WO-2022243877-A1 | PYRROLOPIRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LEISHMANIASIS | DRUGS FOR NEGLECTED DISEASES INITIATIVE (CH) | 2022-11-24 | — | — | WO | claimed |
| EP-4092030-A1 | PYRROLOPIRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LEISHMANIASIS | Drugs for Neglected Diseases Initiative (CH) | 2022-11-23 | — | — | EP | claimed |
| WO-2020235902-A1 | HETEROCYCLE-FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF | 주식회사 보로노이 (KR) | 2020-11-26 | — | — | WO | claimed |
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | claimed |
| EP-2294071-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. Organon (NL) | 2011-03-16 | — | — | EP | claimed |
| WO-2009124965-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2009-10-15 | — | — | WO | claimed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |
| CN-1863538-A | Nucleoside derivatives for treating hepatitis c virus infection | GENELABS TECHNOLOGIES (US) | 2006-11-15 | — | — | CN | claimed |
| US-20260001887-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2026-01-01 | — | — | US | disclosed |
| EP-4341264-B1 | PYRROLOPIRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LEISHMANIASIS | DRUGS FOR NEGLECTED DISEASES INITIATIVE (CH) | 2025-04-02 | — | — | EP | disclosed |
| CN-115244055-B | Pyrimidine five-membered ring derivative and application thereof | 江苏先声药业有限公司 | 2024-09-03 | — | — | CN | disclosed |
| US-20240132464-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | ACCUTAR BIOTECHNOLOGY INC. (US) | 2024-04-25 | — | — | US | disclosed |
| EP-4341264-A1 | PYRROLOPIRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LEISHMANIASIS | Drugs for Neglected Diseases Initiative (CH) | 2024-03-27 | — | — | EP | disclosed |
| CN-1863538-A | Nucleoside derivatives for treating hepatitis c virus infection | GENELABS TECHNOLOGIES (US) | 2006-11-15 | — | — | CN | disclosed |
| US-20060223797-A1 | ALKYNYL PYRROLOPYRIMIDINES AND RELATED ANALOGS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION | 2006-10-05 | — | — | US | disclosed |
| WO-2006105372-A2 | ALKYNYL PYRROLOPYRIMIDINES AND RELATED ANALOGS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |
| EP-1023889-B1 | A hair lotion for preventing hair loss comprising extracts of hop, rosemary and Swertia, further containing silanodiol salicylate | COLOMER GROUP SPAIN S L (ES) | 2003-04-09 | — | — | EP | disclosed |
| EP-1023889-A1 | A hair lotion for preventing hair loss comprising extracts of hop, rosemary and Swertia, further containing silanodiol salicylate | Revlon Consumer Products Corporation (US) | 2000-08-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223797-A1 | ALKYNYL PYRROLOPYRIMIDINES AND RELATED ANALOGS AS HSP90-INHIBITORS | HSP90AB2P, HSP90AB1, HSP90AA1 | MASP2 2384/4885AOC3 3764/4885NPY5R 4046/4885 |
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | PRKCZ, PRKCQ, PRKCD | MASP2 4501/4885AOC3 4076/4885NPY5R 517/4885 |
| US-20240132464-A1 | HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS | GID4, MDM2, XIAP | MASP2 1701/4885AOC3 3458/4885NPY5R 4509/4885 |
| US-20260001887-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | CDK4, CCNC, CDK2 | MASP2 4849/4885AOC3 3360/4885NPY5R 4510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.