Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | UBE2M | P61081 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744569 | 0.86 | DCUN1D1 (0.52) | DCUN1D1SLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL16227662 | 0.74 | TACR1 (0.47) | DCUN1D1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL17870701 | 0.73 | DCUN1D1 (0.51) | DCUN1D1SLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL1346055 | 0.72 | ALB (0.44) | ALDH1A1 | |
| SCHEMBL526963 | 0.70 | AGER (0.46) | DCUN1D1SLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL5042994 | 0.70 | SLC6A2 (0.53) | DCUN1D1SLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL3811903 | 0.70 | DCUN1D1 (0.58) | DCUN1D1SLC6A2SLC6A4SLC6A3AGER | |
| SCHEMBL3601820 | 0.70 | L3MBTL1 (0.60) | — | |
| SCHEMBL14417236 | 0.70 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3TACR1KCNH2 | |
| SCHEMBL3837699 | 0.70 | SLC6A2 (0.49) | DCUN1D1SLC6A2SLC6A4SLC6A3AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689493-A4 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1689738-A2 | HETEROCYCLIC ANTI-MIGRAINE AGENTS | Bristol-Myers Squibb Company (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1689493-A1 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Pharma Company (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005065779-A1 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |
| WO-2005056550-A2 | HETEROCYCLIC ANTI-MIGRAINE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-06-23 | — | — | WO | disclosed |