Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 15/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586809 | 0.92 | CCR5 (0.50) | CCR5KCNH2CACNA1BDCUN1D1SLC6A2 | |
| SCHEMBL4586727 | 0.89 | CCR5 (0.51) | CCR5KCNH2CACNA1BDCUN1D1 | |
| SCHEMBL4587068 | 0.86 | CCR5 (0.48) | CCR5KCNH2CACNA1BHTRA1DCUN1D1 | |
| SCHEMBL4587080 | 0.86 | CCR5 (0.51) | CCR5KCNH2CACNA1BDCUN1D1 | |
| SCHEMBL4586226 | 0.86 | CCR5 (0.50) | CCR5KCNH2DCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL4241269 | 0.85 | CCR5 (0.67) | CCR5 | |
| SCHEMBL4587438 | 0.84 | CCR5 (0.50) | CCR5KCNH2CACNA1BDCUN1D1 | |
| SCHEMBL4587688 | 0.82 | CCR5 (0.41) | CCR5 | |
| SCHEMBL4586351 | 0.82 | CCR5 (0.51) | CCR5KCNH2CACNA1B | |
| SCHEMBL4585482 | 0.82 | CCR5 (0.51) | CCR5KCNH2DCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |