Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23286240 | 0.83 | HCAR3 (0.48) | ALDH1A1RAB9AMAPTPTGER4LMNA | |
| SCHEMBL29737942 | 0.83 | HCAR3 (0.48) | ALDH1A1RAB9AMAPTPTGER4LMNA | |
| SCHEMBL4892950 | 0.82 | MAPT (0.42) | ALDH1A1RAB9AMAPTPTGER4LMNA | |
| SCHEMBL41694 | 0.81 | HRH3 (0.48) | ALDH1A1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL41573 | 0.80 | MEN1 (0.50) | RAB9AMAPTLMNAKMT2AMAPK1 | |
| SCHEMBL14159557 | 0.80 | PTGER4 (0.46) | ALDH1A1RAB9AMAPTPTGER4LMNA | |
| SCHEMBL740933 | 0.77 | MAPT (0.56) | ALDH1A1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL741498 | 0.77 | TXNRD1 (0.48) | ALDH1A1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL4590756 | 0.77 | ALDH1A1 (0.57) | ALDH1A1RAB9AMAPTPTGER4LMNA | |
| SCHEMBL30983656 | 0.75 | MAPT (0.40) | ALDH1A1RAB9AMAPTPTGER4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146536-A1 | 2-Aminoimidazopyridines for treating neurodegenerative diseases | PHARMACOPEIA, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146536-A1 | 2-Aminoimidazopyridines for treating neurodegenerative diseases | PHARMACOPEIA, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146536-A1 | 2-Aminoimidazopyridines for treating neurodegenerative diseases | PHARMACOPEIA, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| WO-2007022305-A2 | 2-AMINOIMIDAZOPYRIDINES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
| WO-2007022305-A2 | 2-AMINOIMIDAZOPYRIDINES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146536-A1 | 2-Aminoimidazopyridines for treating neurodegenerative diseases | ADORA2A, ADORA1, ADORA3 | ALDH1A1 885/4885RAB9A 1725/4885MAPT 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.