Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1821309 | 0.89 | HIF1A (0.50) | ERN1MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL4590421 | 0.76 | ALDH1A1 (0.55) | MEN1KMT2AHPGDALDH1A1TAAR1 | |
| SCHEMBL29168148 | 0.76 | NQO2 (0.57) | MEN1KMT2AHPGDALDH1A1CYP3A4 | |
| SCHEMBL4535306 | 0.75 | HIF1A (0.51) | MEN1KMT2ATAAR1HIF1ACNR1 | |
| SCHEMBL6999007 | 0.71 | CASP1 (0.46) | ERN1MEN1KMT2AALDH1A1CASP1 | |
| SCHEMBL20146223 | 0.71 | ERN1 (0.47) | ERN1MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL28259385 | 0.71 | FAAH (0.65) | MEN1KMT2AFAAHTRPV1CYP1A2 | |
| SCHEMBL13055388 | 0.71 | MAPT (0.42) | ERN1MEN1KMT2ACASP1CYP3A4 | |
| SCHEMBL807757 | 0.71 | HIF1A (0.54) | KMT2AHPGDALDH1A1TAAR1HIF1A | |
| SCHEMBL15468130 | 0.71 | HIF1A (0.54) | KMT2AHPGDALDH1A1TAAR1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |