Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574395 | 0.89 | HCAR2 (0.35) | ALDH1A1RBP4 | |
| SCHEMBL4596912 | 0.84 | LMNA (0.35) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4574346 | 0.84 | HTT (0.34) | KDM4EALDH1A1SMN1; SMN2RBP4LMNA | |
| SCHEMBL4573882 | 0.83 | SMN1; SMN2 (0.34) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4595427 | 0.83 | LMNA (0.35) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4575118 | 0.82 | HCRTR1 (0.30) | — | |
| SCHEMBL4597065 | 0.82 | HCRTR1 (0.33) | SMN1; SMN2LMNAHPGD | |
| SCHEMBL4574391 | 0.77 | MEN1 (0.30) | — | |
| SCHEMBL5411682 | 0.75 | ATP4A (0.44) | POLBMAPK1KDM4EALDH1A1CCNA2 | |
| SCHEMBL4574520 | 0.73 | SMN1; SMN2 (0.38) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071766-A2 | SPIRO-INDENE SUBSTITUTED IMIDAZONAPHYTHYRIDINE AND PYRANOIMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF GASTRIC ACID SECRETION | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |