Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589971 | 0.82 | ALDH1A1 (0.37) | HTTKMT2AMAPTALDH1A1CYP2C19 | |
| SCHEMBL9049034 | 0.82 | MAPT (0.44) | HTTKMT2AMAPTCYP2C19SMN1; SMN2 | |
| SCHEMBL28939289 | 0.76 | LMNA (0.33) | MAPTTSHRLMNACHRM2CHRM1 | |
| SCHEMBL22115533 | 0.75 | MAPT (0.33) | KMT2AMAPTCYP2C19KIF11CYP1A2 | |
| SCHEMBL4375323 | 0.74 | CYP2C19 (0.49) | HTTKMT2AMAPTALDH1A1CYP2C19 | |
| SCHEMBL2969422 | 0.73 | MAPT (0.48) | KMT2AMAPTALDH1A1CYP2C19TSHR | |
| SCHEMBL4588810 | 0.72 | CYP2C19 (0.47) | HTTALDH1A1CYP2C19SMN1; SMN2CYP2D6 | |
| SCHEMBL18426754 | 0.71 | CYP2C19 (0.53) | CYP2C19SMN1; SMN2CYP2D6CYP1A2PKM | |
| SCHEMBL28738770 | 0.69 | MAPT (0.47) | HTTKMT2AMAPTALDH1A1CYP2C19 | |
| SCHEMBL11005490 | 0.69 | HTT (0.55) | HTTKMT2AMAPTALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |