Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598586 | 0.83 | ALDH1A1 (0.36) | ALDH1A1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL4591081 | 0.80 | CYP1A2 (0.33) | ALDH1A1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL7253183 | 0.75 | — | — | |
| SCHEMBL18938655 | 0.66 | — | — | |
| SCHEMBL9646646 | 0.64 | GRM2 (0.31) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL9649202 | 0.63 | MEN1 (0.35) | ALDH1A1MEN1GAAMAPTKMT2A | |
| SCHEMBL4463309 | 0.62 | CYP2A6 (0.33) | — | |
| SCHEMBL18938764 | 0.61 | — | — | |
| SCHEMBL18782552 | 0.61 | MAOB (0.39) | PTGS2PTGS1RAB9AMAOB | |
| SCHEMBL257619 | 0.61 | KIF11 (0.49) | PTGS2PTGS1ALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909775-A2 | FORMULATION OF RADIOPROTECTIVE ALPHA, BETA UNSATURATED ARYL SULFONES | Onconova Therapeutics, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016201-A2 | FORMULATION OF RADIOPROTECTIVE α, β UNSATURATED ARYL SULFONES | ONCONOVA THERAPEUTICS, INC. (US) | 2007-02-08 | — | — | WO | disclosed |