SCHEMBL4591081

SCHEMBL4591081

Clc1ccc(-c2[c]scc2Br)cc1

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.33
LMNA P02545 1/20 0.32
CYP2A6 P11509 1/20 0.32
ALDH1A1 P00352 2/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32
IDO1 P14902 1/20 0.32
PPARG P37231 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
NCOA2 Q15596 1/20 0.32
NCOA1 Q15788 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CASP3 P42574 1/20 0.31
MAOB P27338 1/20 0.31
AHR P35869 1/20 0.30
ALAD P13716 1/20 0.30
GFER P55789 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4598586 0.83 ALDH1A1 (0.36) LMNACYP2A6ALDH1A1MEN1MAPT
SCHEMBL4463309 0.69 CYP2A6 (0.33) CYP2A6
SCHEMBL1177773 0.66
SCHEMBL10407504 0.64 PTGS2 (0.36) CYP1A2LMNAMAPTKMT2ACASP3
SCHEMBL9265689 0.64 CYP1A2 (0.38) CYP1A2LMNACYP2A6AHR
SCHEMBL1416545 0.61 CYP1A2 (0.44) CYP1A2LMNACYP2A6ALDH1A1MEN1
SCHEMBL4591164 0.61 CYP1A2 (0.39) CYP1A2LMNACYP2A6ALDH1A1MEN1
SCHEMBL15253915 0.60 CASP3 (0.35) CYP1A2LMNAMEN1POLBMAPT
SCHEMBL28215 0.60 CYP1A2 (0.73) CYP1A2LMNACYP2A6ALDH1A1POLB
SCHEMBL11165087 0.60 CYP1A2 (0.73) CYP1A2LMNACYP2A6ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1909775-A2 FORMULATION OF RADIOPROTECTIVE ALPHA, BETA UNSATURATED ARYL SULFONES Onconova Therapeutics, Inc. (US) 2008-04-16 EP disclosed
WO-2007016201-A2 FORMULATION OF RADIOPROTECTIVE α, β UNSATURATED ARYL SULFONES ONCONOVA THERAPEUTICS, INC. (US) 2007-02-08 WO disclosed