Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1266484 | 0.83 | LMNA (0.41) | CYP1A2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL4588961 | 0.83 | TRPM8 (0.42) | CYP1A2LMNATRPM8TSHRPOLB | |
| SCHEMBL4590950 | 0.80 | TAS2R14 (0.45) | LMNATRPM8TSHRPOLBSMN1; SMN2 | |
| SCHEMBL28661271 | 0.80 | KCNH2 (0.41) | LMNATRPM8TSHRPOLBSMN1; SMN2 | |
| SCHEMBL21294175 | 0.79 | TRPM8 (0.35) | CYP1A2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL20677823 | 0.74 | ALDH1A1 (0.39) | SMN1; SMN2KMT2AALDH1A1RAB9A | |
| SCHEMBL12640354 | 0.71 | ALDH1A1 (0.42) | LMNAMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL27765172 | 0.70 | TACR2 (0.40) | CYP1A2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL1267086 | 0.69 | KDM4E (0.39) | LMNATRPM8BCL2A1POLBSMN1; SMN2 | |
| SCHEMBL15652468 | 0.69 | TRPM8 (0.42) | CYP1A2CYP3A4CYP2C9CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |