Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4501629 | 0.78 | PKM (0.50) | KITPKMPGRMEN1GFER | |
| SCHEMBL4500689 | 0.77 | PKM (0.48) | PKMPGR | |
| SCHEMBL4501662 | 0.77 | PKM (0.48) | KITPKMPGRMEN1GFER | |
| SCHEMBL4504642 | 0.72 | PKM (0.50) | KITPKMPGRMEN1GFER | |
| SCHEMBL4491585 | 0.70 | PKM (0.48) | KITPKMPGRMEN1GFER | |
| SCHEMBL3291973 | 0.70 | PGR (0.50) | PGRCCR4SLC40A1PIK3C2BPIK3C2G | |
| SCHEMBL4591167 | 0.69 | SLC40A1 (0.54) | PKMPGRCCR4EDNRBEDNRA | |
| SCHEMBL526674 | 0.68 | PKM (0.64) | KITPKMPGRMEN1KMT2A | |
| SCHEMBL16433207 | 0.66 | PKM (0.54) | KITPKMPGRMEN1GFER | |
| SCHEMBL8629936 | 0.66 | MAPK14 (0.42) | MEN1KMT2ASLC40A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789041-B1 | ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |