Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 4/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CCR4 | P51679 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4500427 | 0.74 | ALDH1A1 (0.56) | SLC40A1PGRKDM1APKMCCR4 | |
| SCHEMBL4510017 | 0.72 | PKM (0.52) | TSHRPGRKDM1APKMCCR4 | |
| SCHEMBL3171049 | 0.72 | SLC40A1 (0.71) | SLC40A1PGRCCR4EDNRBEDNRA | |
| SCHEMBL8624736 | 0.72 | SLC40A1 (0.62) | SLC40A1PGRHTT | |
| SCHEMBL3055398 | 0.71 | CA12 (0.46) | SLC40A1TSHRPGRKDM1APKM | |
| SCHEMBL6980378 | 0.70 | SLC40A1 (1.00) | SLC40A1 | |
| SCHEMBL8628072 | 0.70 | ERBB2 (0.45) | PGRKDM1APTGES2KDRFLT1 | |
| SCHEMBL4591228 | 0.69 | KIT (0.46) | SLC40A1PGRPKMCCR4EDNRB | |
| SCHEMBL3291973 | 0.69 | PGR (0.50) | SLC40A1TSHRPGRCCR4KDM4E | |
| SCHEMBL4503018 | 0.69 | KDM1A (0.57) | PGRKDM1APKMEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789041-B1 | ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |