Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.67 |
| ▸ | XBP1 | P17861 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.67 |
| ▸ | TUBB | P07437 | 6/20 | 0.67 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.67 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.67 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.67 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.67 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.67 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.67 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.67 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.67 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.67 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.67 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.67 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.67 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592152 | 0.88 | KDM4E (0.61) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL9437968 | 0.88 | TUBB4A (0.65) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL5161760 | 0.87 | ALDH1A1 (0.60) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL20562711 | 0.85 | KDM4E (0.60) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL4592847 | 0.84 | GPR35 (0.65) | ALDH1A1HPGDTUBB4ATUBBTUBA3C | |
| SCHEMBL4592574 | 0.84 | ALDH1A1 (0.73) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL11298738 | 0.84 | ALDH1A1 (0.69) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL11301354 | 0.84 | ALDH1A1 (0.76) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL14527692 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL6848791 | 0.82 | ALDH1A1 (0.78) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080226718-A1 | Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases | BRANE DISCOVERY S.R.L (IT) | 2008-09-18 | — | — | US | claimed |
| EP-1945305-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRANE DISCOVERY S.R.L. (IT) | 2008-07-23 | — | — | EP | claimed |
| US-20070248672-A1 | Indole and Azaindole Derivatives with Antitumor Action | NIKEM RESEARCH S.R.L. (IT) | 2007-10-25 | — | — | US | claimed |
| WO-2007048847-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | NIKEM RESEARCH S.R.L. (IT) | 2007-05-03 | — | — | WO | claimed |
| EP-1750687-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2007-02-14 | — | — | EP | claimed |
| WO-2005105213-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2005-11-10 | — | — | WO | claimed |
| US-20080226718-A1 | Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases | BRANE DISCOVERY S.R.L (IT) | 2008-09-18 | — | — | US | disclosed |
| EP-1945305-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRANE DISCOVERY S.R.L. (IT) | 2008-07-23 | — | — | EP | disclosed |
| US-20070248672-A1 | Indole and Azaindole Derivatives with Antitumor Action | NIKEM RESEARCH S.R.L. (IT) | 2007-10-25 | — | — | US | disclosed |
| US-20070248672-A1 | Indole and Azaindole Derivatives with Antitumor Action | NIKEM RESEARCH S.R.L. (IT) | 2007-10-25 | — | — | US | disclosed |
| US-20070248672-A1 | Indole and Azaindole Derivatives with Antitumor Action | NIKEM RESEARCH S.R.L. (IT) | 2007-10-25 | — | — | US | disclosed |
| WO-2007048847-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | NIKEM RESEARCH S.R.L. (IT) | 2007-05-03 | — | — | WO | disclosed |
| EP-1750687-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005105213-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070248672-A1 | Indole and Azaindole Derivatives with Antitumor Action | IDO1, IDO2, INMT | ALDH1A1 788/4885HPGD 253/4885CYP1A2 264/4885 |
| US-20080226718-A1 | Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases | IDO1, IDO2, INMT | ALDH1A1 1731/4885HPGD 953/4885CYP1A2 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.