Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.58 |
| ▸ | TUBB | P07437 | 6/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.58 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.58 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.58 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.58 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.58 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.58 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.58 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14527878 | 0.92 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL4591940 | 0.88 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL9437968 | 0.86 | TUBB4A (0.65) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL20562711 | 0.85 | KDM4E (0.60) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL11349765 | 0.81 | ALDH1A1 (0.55) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL7528226 | 0.81 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL4592690 | 0.77 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL14174310 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL5161760 | 0.75 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL14527768 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1HPGDGAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080226718-A1 | Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases | BRANE DISCOVERY S.R.L (IT) | 2008-09-18 | — | — | US | claimed |
| EP-1945305-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRANE DISCOVERY S.R.L. (IT) | 2008-07-23 | — | — | EP | claimed |
| WO-2007048847-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | NIKEM RESEARCH S.R.L. (IT) | 2007-05-03 | — | — | WO | claimed |
| EP-1750687-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2007-02-14 | — | — | EP | claimed |
| WO-2005105213-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2005-11-10 | — | — | WO | claimed |
| US-20080317857-A1 | V-Atpase Inhibitors of Use in the Treatment of Septic Shock | BRANE DISCOVERY S.R.L. (IT) | 2008-12-25 | — | — | US | disclosed |
| US-20080317857-A1 | V-Atpase Inhibitors of Use in the Treatment of Septic Shock | BRANE DISCOVERY S.R.L. (IT) | 2008-12-25 | — | — | US | disclosed |
| US-20080226718-A1 | Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases | BRANE DISCOVERY S.R.L (IT) | 2008-09-18 | — | — | US | disclosed |
| US-20080226718-A1 | Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases | BRANE DISCOVERY S.R.L (IT) | 2008-09-18 | — | — | US | disclosed |
| US-20080226718-A1 | Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases | BRANE DISCOVERY S.R.L (IT) | 2008-09-18 | — | — | US | disclosed |
| EP-1945305-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRANE DISCOVERY S.R.L. (IT) | 2008-07-23 | — | — | EP | disclosed |
| US-20070248672-A1 | Indole and Azaindole Derivatives with Antitumor Action | NIKEM RESEARCH S.R.L. (IT) | 2007-10-25 | — | — | US | disclosed |
| WO-2007048847-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | NIKEM RESEARCH S.R.L. (IT) | 2007-05-03 | — | — | WO | disclosed |
| EP-1779848-A1 | V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases | NIKEM RESEARCH S.R.L. (IT) | 2007-05-02 | — | — | EP | disclosed |
| EP-1779849-A1 | V-ATPase inhibitors for the treatment of septic shock | NIKEM RESEARCH S.R.L. (IT) | 2007-05-02 | — | — | EP | disclosed |
| EP-1750687-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005105213-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070248672-A1 | Indole and Azaindole Derivatives with Antitumor Action | IDO1, IDO2, INMT | KDM4E 512/4885ALDH1A1 788/4885HPGD 253/4885 |
| US-20080226718-A1 | Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases | IDO1, IDO2, INMT | KDM4E 902/4885ALDH1A1 1731/4885HPGD 953/4885 |
| US-20080317857-A1 | V-Atpase Inhibitors of Use in the Treatment of Septic Shock | ATP6V1E1, ATP6V1H, ATP6V1G1 | KDM4E 3457/4885ALDH1A1 4432/4885HPGD 1005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.