Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 4/20 | 0.51 |
| ▸ | TDP2 | O95551 | 4/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.51 |
| ▸ | S100A4 | P26447 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.48 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.48 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10509896 | 0.91 | KMT2A (0.58) | NSD2TDP2PAX8S100A4KMT2A | |
| SCHEMBL30587670 | 0.77 | MAOA (0.58) | NSD2TDP2PAX8KMT2AMEN1 | |
| SCHEMBL2531942 | 0.77 | MAOA (0.58) | NSD2TDP2PAX8KMT2AMEN1 | |
| SCHEMBL458428 | 0.75 | S100A4 (0.68) | NSD2TDP2PAX8S100A4KMT2A | |
| SCHEMBL31238099 | 0.74 | MEN1 (0.78) | NSD2TDP2PAX8S100A4KMT2A | |
| SCHEMBL459004 | 0.68 | NSD2 (1.00) | NSD2TDP2PAX8S100A4KMT2A | |
| SCHEMBL29551149 | 0.66 | GAA (1.00) | NSD2TDP2PAX8S100A4KMT2A | |
| SCHEMBL30774319 | 0.66 | GAA (1.00) | NSD2TDP2PAX8S100A4KMT2A | |
| SCHEMBL29419580 | 0.66 | TDP2 (1.00) | NSD2TDP2PAX8S100A4KMT2A | |
| SCHEMBL5915065 | 0.66 | TDP2 (0.81) | NSD2TDP2PAX8S100A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | EMORY UNIVERSITY (US) | 2012-01-26 | — | — | US | claimed |
| WO-2010042500-A2 | HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE | EMORY UNIVERSITY (US) | 2010-04-15 | — | — | WO | claimed |
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | EMORY UNIVERSITY (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010042500-A2 | HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE | EMORY UNIVERSITY (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | HSP90AB1, HSP90AA1, HSP90AB2P | NSD2 4199/4885TDP2 707/4885PAX8 4091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.