Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631052 | 0.73 | IDO1 (0.41) | KMT2A | |
| SCHEMBL27504338 | 0.72 | PTGS2 (0.45) | KMT2A | |
| SCHEMBL28019331 | 0.69 | GRIN2D (0.33) | — | |
| SCHEMBL9549828 | 0.67 | MAPT (0.46) | L3MBTL1KMT2A | |
| SCHEMBL30190420 | 0.67 | ESR1 (0.31) | EGFR | |
| SCHEMBL7421540 | 0.67 | — | — | |
| SCHEMBL9033202 | 0.67 | IDO1 (0.41) | L3MBTL1KMT2A | |
| SCHEMBL8003064 | 0.67 | TRPV4 (0.40) | — | |
| SCHEMBL27779512 | 0.67 | ELANE (0.32) | — | |
| SCHEMBL30135699 | 0.67 | CYP1A2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101137660-B | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives as antidiabetic compounds | HOFFMANN LA ROCHE | 2011-06-15 | — | — | CN | disclosed |
| CN-101253171-B | Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives | HOFFMANN LA ROCHE | 2011-06-15 | — | — | CN | disclosed |
| CN-101679260-A | 4,4-disubstituted piperidine derivatives | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |
| CN-101679368-A | Aryl azoles, aryl diazole and benzimidizole derivatives | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |
| CN-101646665-A | 1-(1-benzyl piepridine-4-yl) benzoglyoxaline-5-carboxylic acid derivative that is used for the treatment of diabetes | HOFFMANN LA ROCHE CH | 2010-02-10 | — | — | CN | disclosed |
| CN-101511817-A | Pyridine-and quinoline-pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | CN | disclosed |
| CN-101479257-A | Pyrimidine and quinazoline derivatives | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-101405284-A | Pyrimidine, quinazoline, pteridine and derivatives | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |
| CN-101253171-A | Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives | HOFFMANN LA ROCHE (CH) | 2008-08-27 | — | — | CN | disclosed |
| CN-101189226-A | Piperidin-4-yl-amide derivatives and their use as SST receptor subtype 5 antagonists | HOFFMANN LA ROCHE (CH) | 2008-05-28 | — | — | CN | disclosed |
| EP-1893603-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| CN-101137660-A | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives as antidiabetic compounds | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | CN | disclosed |
| WO-2006128803-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-07 | — | — | WO | disclosed |