Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | G6PD | P11413 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13496984 | 1.00 | MEN1 (0.71) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL15423059 | 0.85 | HDAC3 (0.60) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL4115183 | 0.83 | MEN1 (0.77) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL333482 | 0.83 | MEN1 (1.00) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL9067815 | 0.83 | MEN1 (1.00) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL4115180 | 0.83 | MEN1 (0.77) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL549490 | 0.83 | MEN1 (1.00) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL31588094 | 0.83 | MEN1 (0.77) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL78287 | 0.83 | MEN1 (1.00) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL1562814 | 0.83 | KMT2A (0.65) | MEN1KMT2ARAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |
| US-7534905-B2 | Reagents for asymmetric allylation, aldol, and tandem aldol and allyation reactions | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-05-19 | — | — | US | disclosed |
| US-7534905-B2 | Reagents for asymmetric allylation, aldol, and tandem aldol and allyation reactions | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-05-19 | — | — | US | disclosed |
| EP-1480988-A4 | REAGENTS FOR ASYMMETRIC ALLYLATION, ALDOL, AND TANDEM ALDOL AND ALLYLATION REACTIONS | UNIV COLUMBIA (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050288525-A1 | Reagents for asymmetric allylation, aldol, and tandem aldol and allylation reactions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-12-29 | — | — | US | disclosed |
| CN-1639172-A | Reagents for asymmetric allylation, aldol, and tandem aldol and allylation reactions | UNIV COLUMBIA (US) | 2005-07-13 | — | — | CN | disclosed |
| EP-1480988-A1 | REAGENTS FOR ASYMMETRIC ALLYLATION, ALDOL, AND TANDEM ALDOL AND ALLYLATION REACTIONS | The Trustees of Columbia University in the City of New York (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003074534-A9 | REAGENTS FOR ASYMMETRIC ALLYLATION, ALDOL, AND TANDEM ALDOL AND ALLYLATION REACTIONS | UNIV COLUMBIA (US) | 2003-11-20 | — | — | WO | disclosed |
| WO-2003074534-A1 | REAGENTS FOR ASYMMETRIC ALLYLATION, ALDOL, AND TANDEM ALDOL AND ALLYLATION REACTIONS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288525-A1 | Reagents for asymmetric allylation, aldol, and tandem aldol and allylation reactions | AKR1C3, AKR1B10, CBR3 | MEN1 3759/4885KMT2A 3237/4885RAB9A 1076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.