Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 4/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.34 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5180971 | 0.74 | KDM4E (0.40) | TRPV1DHODHPTGER1 | |
| SCHEMBL19437767 | 0.72 | TSPO (0.39) | KDM4CDHODHPTGER1 | |
| SCHEMBL312869 | 0.68 | KDM4E (0.46) | KDM2BKDM4CP2RY14MAPK1 | |
| SCHEMBL18365964 | 0.68 | TAS2R14 (0.37) | PTGER1 | |
| SCHEMBL1348829 | 0.67 | ADORA3 (0.39) | KDM2BKDM4CP2RY14 | |
| SCHEMBL29893015 | 0.67 | MCHR1 (0.45) | TRPV1KDM2BKDM4CPLAUDHODH | |
| SCHEMBL14881703 | 0.66 | KMO (0.53) | — | |
| SCHEMBL2468818 | 0.65 | PLAU (0.49) | TRPV1PLAUDHODHMAPK1MAP2K4 | |
| SCHEMBL3692564 | 0.65 | MARS1 (0.39) | DHODHP2RY14 | |
| SCHEMBL17941413 | 0.65 | CFTR (0.42) | PLAUDHODHMAPK1MAP2K4MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934214-A1 | OXADIAZOLYL PYRAZOLO-PYRIMIDINES AS MGLUR2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007039439-A1 | OXADIAZOLYL PYRAZOLO-PYRIMIDINES AS MGLUR2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-12 | — | — | WO | disclosed |