Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 17/20 | 0.50 |
| ▸ | CTSS | P25774 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.46 |
| ▸ | CTSB | P07858 | 4/20 | 0.45 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | SDHB | P21912 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3875432 | 0.92 | SDHB (0.51) | KCNH2SDHBMEN1S1PR4LMNA | |
| SCHEMBL3873029 | 0.90 | CTSK (0.57) | CTSKCTSSKCNH2CTSBCTSL | |
| SCHEMBL14267874 | 0.77 | SQOR (0.59) | CTSKCTSSMAPK1RAB9A | |
| SCHEMBL5593061 | 0.76 | SDHB (0.68) | SDHBMEN1S1PR4LMNATP53 | |
| SCHEMBL3875774 | 0.74 | LMNA (0.46) | CTSKCTSSLMNAHPGDHSD17B10 | |
| SCHEMBL3874622 | 0.73 | CTSK (0.60) | CTSKCTSSKCNH2CTSBCTSL | |
| SCHEMBL8560362 | 0.73 | SDHB (0.56) | SDHBMEN1S1PR4LMNATP53 | |
| SCHEMBL3877426 | 0.72 | CTSK (0.68) | CTSKCTSSKCNH2CTSBCTSL | |
| SCHEMBL27739899 | 0.72 | PTPN1 (0.42) | CTSKCTSSMEN1KMT2A | |
| SCHEMBL19805611 | 0.72 | SDHB (0.74) | KCNH2SDHBMEN1S1PR4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928842-A1 | 4-PHENYL-6-SUBSTITUTED-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. Organon (NL) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007039470-A1 | 4-PHENYL-6-SUBSTITUTED-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. ORGANON (NL) | 2007-04-12 | — | — | WO | disclosed |