Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 10/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | HTT | P42858 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | STAT3 | P40763 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | STAT1 | P42224 | 2/20 | 0.56 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MITF | O75030 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559618 | 0.81 | NUDT1 (0.44) | HPGDHTTLMNASTAT3RAB9A | |
| SCHEMBL8558749 | 0.81 | NUDT1 (0.44) | HPGDHTTLMNASTAT3RAB9A | |
| SCHEMBL8558105 | 0.81 | ALDH1A1 (0.48) | NPSR1HPGDHTTLMNASTAT3 | |
| SCHEMBL8562901 | 0.80 | SMN1; SMN2 (0.45) | HPGDHTTLMNASTAT3RAB9A | |
| SCHEMBL19805611 | 0.79 | SDHB (0.74) | SDHBNPSR1HPGDHTTLMNA | |
| SCHEMBL3875432 | 0.79 | SDHB (0.51) | SDHBNPSR1HPGDHTTLMNA | |
| SCHEMBL30638939 | 0.77 | NUDT1 (0.42) | NPSR1LMNAKDM4EALDH1A1 | |
| SCHEMBL22767478 | 0.76 | SMN1; SMN2 (0.45) | HPGDHTTLMNAKMT2AMAPK1 | |
| SCHEMBL8561459 | 0.76 | PTGES (0.43) | HPGDHTTKMT2AMAPK1MEN1 | |
| SCHEMBL8446796 | 0.76 | LMNA (0.68) | SDHBNPSR1HPGDHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101268058-B | 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives | MSD OSS BV | 2013-02-27 | — | — | CN | disclosed |
| CN-101268058-A | 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives | ORGANON NV (NL) | 2008-09-17 | — | — | CN | disclosed |
| US-5726128-A | Benzyloxypyrimidine derivative, processes for producing the same and herbicidal composition | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0707001-A1 | Benzyloxypyrimidine derivative, processes for producing the same and herbicidal composition | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1996-04-17 | — | — | EP | disclosed |