Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779174 | 0.91 | RAB9A (0.39) | RAB9ANPC1CSF1RKDM4EALDH1A1 | |
| SCHEMBL1780244 | 0.81 | HSD17B10 (0.38) | RAB9ANPC1CSF1RKDM4EALDH1A1 | |
| SCHEMBL3866037 | 0.81 | RAB9A (0.43) | RAB9ANPC1CSF1RKDM4EALDH1A1 | |
| SCHEMBL1779652 | 0.80 | RXFP1 (0.36) | RAB9ANPC1CSF1RKDM4EALDH1A1 | |
| SCHEMBL4592913 | 0.79 | ITGA4 (0.34) | RAB9ANPC1CSF1RKDM4EALDH1A1 | |
| SCHEMBL1777881 | 0.77 | HSD17B10 (0.35) | RAB9ANPC1CSF1RKDM4EALDH1A1 | |
| SCHEMBL1778607 | 0.77 | ALDH1A1 (0.38) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1780614 | 0.76 | RAF1 (0.42) | CSF1RFLT3 | |
| SCHEMBL1779425 | 0.75 | MAPK1 (0.46) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1779165 | 0.74 | KDM4E (0.38) | RAB9AKDM4EALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904503-A1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007009898-A1 | 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-01-25 | — | — | WO | disclosed |