Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 4/20 | 0.33 |
| ▸ | PPARA | Q07869 | 4/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.33 |
| ▸ | BRS3 | P32247 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594697 | 0.92 | GAA (0.41) | KDM4EIDH1HTR2ASLC6A2SLC6A4 | |
| SCHEMBL4593462 | 0.88 | RAB9A (0.40) | NPC1CMKLR1IDH1HTR2AMAPT | |
| SCHEMBL4593394 | 0.86 | SLC6A2 (0.36) | HTR2ASSTR5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4594412 | 0.86 | HDAC6 (0.38) | KDM4ENPC1ALDH1A1IDH1HTR2A | |
| SCHEMBL4594214 | 0.83 | MAPK1 (0.36) | KDM4EALDH1A1MAPK1HTR2ASSTR5 | |
| SCHEMBL4594611 | 0.83 | TP53 (0.38) | KDM4ENPC1ALDH1A1IDH1HTR2A | |
| SCHEMBL4594452 | 0.82 | SSTR5 (0.41) | KDM4ENPC1ALDH1A1MAPK1CMKLR1 | |
| SCHEMBL4593207 | 0.82 | SSTR5 (0.36) | ALDH1A1HTR2ASSTR5SLC6A2SLC6A4 | |
| SCHEMBL4594418 | 0.81 | PPARD (0.37) | HTR2ASSTR5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4594500 | 0.81 | PPARD (0.35) | SSTR5SLC6A2SLC6A4SLC6A3PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | claimed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | claimed |
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |