Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 18/20 | 0.35 |
| ▸ | PPARA | Q07869 | 18/20 | 0.35 |
| ▸ | PPARG | P37231 | 13/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594418 | 0.92 | PPARD (0.37) | PPARDPPARAPPARGSLC6A2SLC6A4 | |
| SCHEMBL4593880 | 0.88 | SLC6A2 (0.36) | PPARDPPARAPPARGSLC6A2SLC6A4 | |
| SCHEMBL4594214 | 0.87 | MAPK1 (0.36) | PPARDPPARAPPARGSLC6A2SLC6A4 | |
| SCHEMBL4594555 | 0.87 | TSHR (0.34) | PPARDPPARAPPARGSLC6A2SLC6A4 | |
| SCHEMBL4593207 | 0.85 | SSTR5 (0.36) | PPARDPPARAPPARGSLC6A2SLC6A4 | |
| SCHEMBL4593394 | 0.83 | SLC6A2 (0.36) | PPARDPPARAPPARGSLC6A2SLC6A4 | |
| SCHEMBL4594412 | 0.83 | HDAC6 (0.38) | PPARDPPARAPPARGSSTR5 | |
| SCHEMBL4594697 | 0.82 | GAA (0.41) | PPARDPPARAPPARGSLC6A2SLC6A4 | |
| SCHEMBL4593462 | 0.81 | RAB9A (0.40) | SSTR5 | |
| SCHEMBL4593931 | 0.81 | KDM4E (0.40) | PPARDPPARAPPARGSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | claimed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | claimed |
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |