Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593462 | 0.93 | RAB9A (0.40) | TP53MBTPS1MAPTTHRBELANE | |
| SCHEMBL4593295 | 0.92 | TP53 (0.39) | TP53MBTPS1SSTR5HTR2AKDM4E | |
| SCHEMBL4594412 | 0.85 | HDAC6 (0.38) | TP53MBTPS1MAPTTHRBSSTR5 | |
| SCHEMBL4593931 | 0.83 | KDM4E (0.40) | MBTPS1MAPTSSTR5HTR2AKDM4E | |
| SCHEMBL4593756 | 0.82 | SSTR5 (0.47) | TP53CTSLCTSSMAPTSSTR5 | |
| SCHEMBL4594089 | 0.82 | SSTR5 (0.39) | TP53MAPTSSTR5KDM4ENPC1 | |
| SCHEMBL4593912 | 0.82 | SSTR5 (0.41) | TP53MAPTSSTR5KDM4ENPC1 | |
| SCHEMBL4593748 | 0.82 | SSTR5 (0.41) | TP53MAPTSSTR5NPC1RAB9A | |
| SCHEMBL4594697 | 0.81 | GAA (0.41) | HTR2AKDM4EIDH1PPARGPPARD | |
| SCHEMBL4593487 | 0.80 | TRPV1 (0.38) | TP53MBTPS1MAPTTHRBHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |