Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CDC25B | P30305 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595403 | 0.79 | MAPT (0.62) | POLBMEN1KMT2AKDM4EHPGD | |
| SCHEMBL7369757 | 0.77 | MAPT (0.51) | CYP2C9MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL4594510 | 0.76 | MAPT (0.54) | POLBCDC25BMEN1KMT2APTGS2 | |
| SCHEMBL11799846 | 0.76 | FTO (0.58) | POLBCDC25BNR4A1NR4A2NR4A3 | |
| SCHEMBL8555568 | 0.73 | PTGS2 (0.71) | POLBCDC25BNR4A1NR4A2FABP3 | |
| SCHEMBL27684870 | 0.73 | ALDH1A1 (0.59) | POLBCDC25BIDO1NR4A1NR4A2 | |
| SCHEMBL13271379 | 0.73 | FABP3 (0.68) | CDC25BFABP3FABP4FABP5AKR1C2 | |
| SCHEMBL16737100 | 0.72 | ANO1 (0.72) | POLBAKR1C2MEN1KMT2ALMNA | |
| SCHEMBL3364068 | 0.72 | POLB (0.60) | POLBFABP4AKR1C2CYP2C9HIF1A | |
| SCHEMBL16737205 | 0.71 | ANO1 (0.62) | POLBAKR1C2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| EP-1937243-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007045593-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | APP, BACE1, SNCA | POLB 1245/4885CDC25B 2914/4885IDO1 2712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.