Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TLR4 | O00206 | 8/20 | 0.54 |
| ▸ | TLR2 | O60603 | 8/20 | 0.54 |
| ▸ | FBP1 | P09467 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459462 | 1.00 | NPC1 (0.58) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL229329 | 0.75 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL9394256 | 0.75 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL229328 | 0.75 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL31560044 | 0.75 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL25013797 | 0.74 | VCP (0.51) | RAB9AKMT2ATLR4TLR2FBP1 | |
| SCHEMBL30272444 | 0.74 | VCP (0.51) | RAB9AKMT2ATLR4TLR2FBP1 | |
| Nitric Acid SCHEMBL28135270 | 0.73 | NPC1 (0.48) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL9058120 | 0.73 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL9805966 | 0.73 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11779018-B2 | Heterocyclic compound and arthropod pest control composition containing same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2023-10-10 | — | — | US | disclosed |
| EP-2970215-B1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBVIE DEUTSCHLAND (DE) | 2019-04-17 | — | — | EP | disclosed |
| US-10246414-B2 | Allosteric modulators of CB1 cannabinoid receptors | NORTHEASTERN UNIVERSITY (US) | 2019-04-02 | — | — | US | disclosed |
| US-10246414-B2 | Allosteric modulators of CB1 cannabinoid receptors | NORTHEASTERN UNIVERSITY (US) | 2019-04-02 | — | — | US | disclosed |
| EP-2800569-B1 | ALLOSTERIC MODULATORS OF CB1 CANNABINOID RECEPTORS | UNIV NORTHEASTERN (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-2800569-B1 | ALLOSTERIC MODULATORS OF CB1 CANNABINOID RECEPTORS | UNIV NORTHEASTERN (US) | 2018-07-25 | — | — | EP | disclosed |
| US-20170197918-A1 | Allosteric Modulators of CB1 Cannabinoid Receptors | NORTHEASTERN UNIVERSITY | 2017-07-13 | — | — | US | disclosed |
| US-20170197918-A1 | Allosteric Modulators of CB1 Cannabinoid Receptors | NORTHEASTERN UNIVERSITY | 2017-07-13 | — | — | US | disclosed |
| US-20170197918-A1 | Allosteric Modulators of CB1 Cannabinoid Receptors | NORTHEASTERN UNIVERSITY | 2017-07-13 | — | — | US | disclosed |
| US-9656955-B2 | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBVIE INC. (US) | 2017-05-23 | — | — | US | disclosed |
| WO-2013103967-A1 | ALLOSTERIC MODULATORS OF CB1 CANNABINOID RECEPTORS | NORTHEASTERN UNIVERSITY (US) | 2013-07-11 | — | — | WO | disclosed |
| WO-2013103967-A1 | ALLOSTERIC MODULATORS OF CB1 CANNABINOID RECEPTORS | NORTHEASTERN UNIVERSITY (US) | 2013-07-11 | — | — | WO | disclosed |
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |
| US-7718801-B2 | Substituted imidazole derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| CN-101668767-A | Pyridine derivatives substituted with heterocyclic ring and phosphonoamino group and antifungal agent containing the same | EISAI R&D MAN CO LTD | 2010-03-10 | — | — | CN | disclosed |
| CN-101300250-A | Heterocyclic substituted pyridine derivative and antifungal agent containing the same | EISAI R&D MAN CO LTD (JP) | 2008-11-05 | — | — | CN | disclosed |
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | MSD K.K. (JP) | 2008-03-20 | — | — | US | disclosed |
| US-7332622-B2 | Process for preparing optically active nitro compounds and cyano compounds | KANTO KAGUKU KABUSHIKI KAISHA (JP) | 2008-02-19 | — | — | US | disclosed |
| EP-1790650-A1 | NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | PLK1, CDK1, CDK11A | NPC1 2808/4885RAB9A 657/4885MEN1 885/4885 |
| US-10246414-B2 | Allosteric modulators of CB1 cannabinoid receptors | CNR1, CNR2, GPR18 | NPC1 1593/4885RAB9A 961/4885MEN1 4653/4885 |
| US-11779018-B2 | Heterocyclic compound and arthropod pest control composition containing same | C5, PRXL2A, NOX3 | NPC1 3948/4885RAB9A 408/4885MEN1 2911/4885 |
| US-20170197918-A1 | Allosteric Modulators of CB1 Cannabinoid Receptors | CNR1, CNR2, GPR18 | NPC1 1593/4885RAB9A 961/4885MEN1 4653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.