SCHEMBL4594654

SCHEMBL4594654

Cc1ccc2c(CC(=O)O)cc3c(c2c1)C=CC(c1ccccc1)(c1ccc([N+]2(C)CCCCC2)cc1)O3

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.32
ALOX15 P16050 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4593620 0.84 MPL (0.33) MAPTALOX15SMN1; SMN2
SCHEMBL5156144 0.73 ALDH1A1 (0.31) MAPT
SCHEMBL4673209 0.65 HTR3E (0.31)
SCHEMBL10026216 0.63 KDM4E (0.32) MAPT
SCHEMBL4607014 0.61
SCHEMBL10026214 0.61 ALDH1A1 (0.32) MAPTSMN1; SMN2
SCHEMBL7128812 0.59 MAPT (0.40) MAPTSMN1; SMN2
SCHEMBL12618090 0.59 NCF1 (0.43) MAPTALOX15SMN1; SMN2
SCHEMBL7126396 0.58 CYP1A2 (0.36) MAPTSMN1; SMN2
SCHEMBL5944497 0.57 POLB (0.42) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1410786-B1 Cosmetic composition comprising at least two dyes whereof at least one is photochromic OREAL (FR) 2008-01-02 EP claimed
EP-1410785-B1 Make-up product, combining two compositions, comprising a photochromic dye and a goniochromatic agent, respectively OREAL (FR) 2007-01-03 EP claimed
US-20040228817-A1 Makeup combining at least one photochromic dye and at least one goniochromatic agent L'OREAL (FR) 2004-11-18 US claimed
US-20040228818-A1 Cosmetic composition combining at least two dyes including at least one photochromic dye L'OREAL (FR) 2004-11-18 US claimed
EP-3989772-B1 METHOD FOR SHAPING AN APPLICATOR FOR APPLYING A COSMETIC COMPOSITION OREAL (FR) 2024-04-10 EP disclosed
EP-4051053-B1 SYSTEM FOR TAKING UP AND APPLYING A COSMETIC COMPOSITION OREAL (FR) 2023-11-08 EP disclosed
EP-3086853-B1 MAKEUP DEVICE COMPRISING A PLURALITY OF COSMETIC DYES OREAL (FR) 2023-08-09 EP disclosed
EP-4218940-A2 TRANSFER DEVICE FOR MAKING UP KERATIN MATERIALS L'OREAL (FR) 2023-08-02 EP disclosed
EP-3086848-B1 TRANSFER DEVICE FOR MAKING UP KERATIN MATERIALS OREAL (FR) 2023-06-07 EP disclosed
US-20220400835-A1 SYSTEM FOR TAKING UP AND APPLYING A COSMETIC COMPOSITION L'OREAL (FR) 2022-12-22 US disclosed
US-20220256996-A1 METHOD FOR SHAPING AN APPLICATOR FOR APPLYING A COSMETIC COMPOSITION L'OREAL (FR) 2022-08-18 US disclosed
EP-3086849-B1 TRANSFER DEVICE FOR MAKING UP KERATIN MATERIALS OREAL (FR) 2019-11-20 EP disclosed
US-10477938-B2 Makeup device comprising a plurality of cosmetic dyes L'OREAL (FR) 2019-11-19 US disclosed
US-20160324298-A1 TRANSFER DEVICE FOR MAKING UP KERATIN MATERIALS L'OREAL (FR) 2016-11-10 US disclosed
US-20160324299-A1 TRANSFER DEVICE FOR MAKING UP KERATIN MATERIALS L'OREAL (FR) 2016-11-10 US disclosed
US-20160316892-A1 TRANSFER DEVICE FOR MAKING UP KERATIN MATERIALS L'OREAL (FR) 2016-11-03 US disclosed
US-20160316886-A1 MAKEUP DEVICE COMPRISING A PLURALITY OF COSMETIC DYES L'OREAL (FR) 2016-11-03 US disclosed
US-20040228817-A1 Makeup combining at least one photochromic dye and at least one goniochromatic agent L'OREAL (FR) 2004-11-18 US disclosed
US-20040228818-A1 Cosmetic composition combining at least two dyes including at least one photochromic dye L'OREAL (FR) 2004-11-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040228817-A1 Makeup combining at least one photochromic dye and at least one goniochromatic agent GYPA, TYR, GLA MAPT 3990/4885ALOX15 1688/4885SMN1; SMN2 3201/4885
US-20160324298-A1 TRANSFER DEVICE FOR MAKING UP KERATIN MATERIALS KRT18, CKAP4, MARK4 MAPT 88/4885ALOX15 4569/4885SMN1; SMN2 4552/4885
US-20040228818-A1 Cosmetic composition combining at least two dyes including at least one photochromic dye CUTA, TYR, LAGE3 MAPT 2972/4885ALOX15 1179/4885SMN1; SMN2 4768/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.