Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596760 | 0.86 | MAPT (0.43) | POLBMAPK14LMNAKDM4ECYP1A2 | |
| SCHEMBL4595116 | 0.82 | PARP1 (0.44) | POLBTRPV1MAPK14NPSR1PKM | |
| SCHEMBL4230647 | 0.79 | AQP1 (0.43) | POLBTRPV1MAPK14LMNASHMT2 | |
| SCHEMBL4711112 | 0.72 | HTR2A (0.36) | MAPK14NPSR1MAPTALDH1A1HTT | |
| SCHEMBL4595476 | 0.70 | L3MBTL1 (0.35) | POLBLMNAKDM4EHPGDALDH1A1 | |
| SCHEMBL4595291 | 0.70 | AQP1 (0.44) | MAPK14NPSR1KDM4ECYP1A2MAPT | |
| SCHEMBL4597588 | 0.69 | HTR7 (0.43) | — | |
| SCHEMBL4595494 | 0.69 | AQP1 (0.36) | — | |
| SCHEMBL4233314 | 0.69 | PRKAB2 (0.44) | SHMT2 | |
| SCHEMBL4222627 | 0.68 | PRKAB2 (0.43) | POLBMAPTHPGDKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |